Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 8187620
APP PUB NO 20070224116A1
SERIAL NO

11390799

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates generally to a medical device, such as an intravascular stent, for delivering a therapeutic agent to the body tissue of a patient, and a method for making such a medical device. More particularly, the invention pertains to a medical device having a metal oxide or metal material with a plurality of pores therein disposed on the surface of the medical device and a polymer disposed on the metal oxide or metal material. The invention also relates to medical devices having a surface and an outer region comprising a metal oxide or metal material having a plurality of pores therein and a polymer disposed on the metal oxide or metal material.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BOSTON SCIENTIFIC SCIMED, INC.MAPLE GROVE, MN5441

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chandrasekaran, Chandru Mercer Island, US 10 362
Radhakrishnan, Rajesh Bothell, US 63 406

Cited Art Landscape

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6652582 Bioabsorbable endoprosthesis having porosity for by-product collection 99 1999
6253443 Method of forming a stent 203 1999
6440503 Laser deposition of elements onto medical devices 50 2000
6368658 Coating medical devices using air suspension 340 2000
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6284305 Drug coating with topcoat 297 2000
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6491666 Microfabricated devices for the delivery of molecules into a carrier fluid 263 2000
6517888 Method for manufacturing a medical device having a coated portion by laser ablation 206 2000
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6398806 Monolayer modification to gold coated stents to reduce adsorption of protein 64 2000
6752829 Stent with channel(s) for containing and delivering a biologically active material and method for manufacturing the same 117 2001
6767360 Vascular stent with composite structure for magnetic reasonance imaging capabilities 83 2001
6607598 Device for protecting medical devices during a coating process 87 2001
6783543 Intravascular stent with increasing coating retaining capacity 143 2001
2001/0029,660 Stent drug delivery system 81 2001
6939320 Localized delivery of drug agents 142 2001
6676987 Coating a medical appliance with a bubble jet printing head 134 2001
6620194 Drug coating with topcoat 78 2001
6669980 Method for spray-coating medical devices 250 2001
6764709 Method for making and measuring a coating on the surface of a medical device using an ultraviolet laser 62 2001
6807440 Ceramic reinforcement members for MRI devices 48 2001
7014654 Stent designed for the delivery of therapeutic substance or other agents 57 2001
2003/0153,971 Metal reinforced biodegradable intraluminal stents 120 2002
2002/0144,757 Stainless steel alloy with improved radiopaque characteristics 85 2002
2003/0018,380 Platinum enhanced alloy and intravascular or implantable medical devices manufactured therefrom 108 2002
2003/0077,200 Enhanced radiopaque alloy stent 98 2002
2003/0236,514 Implantable or insertable medical devices for controlled delivery of a therapeutic agent 105 2002
2004/0022,824 Controlled drug delivery 43 2002
7101391 Primarily niobium stent 54 2002
6908622 Optimized dosing for drug coated stents 81 2002
7060051 Multi-balloon catheter with hydrogel coating 122 2002
2004/0059,409 Method of applying coatings to a medical device 97 2002
6971813 Contact coating of prostheses 78 2002
2004/0098,089 Medical devices 56 2002
2004/0106,987 Medical devices for delivery of therapeutic agents 117 2002
6803070 Apparatus and method for embedding nanoparticles in polymeric medical devices 59 2002
2004/0143,317 Medical devices 207 2003
7402173 Metal stent with surface layer of noble metal oxide and method of fabrication 50 2003
2004/0106,985 Intravascular stent 107 2003
2004/0093,071 Intravascular stent with increasing coating retaining capacity 61 2003
7482034 Expandable mask stent coating method 37 2003
7101394 Energetically-controlled delivery of biologically active material from an implanted medical device 110 2003
2004/0230,290 Medical devices and methods of making the same 68 2003
2004/0234,748 Electrostatic coating of a device 70 2003
7011680 Stent device and method 70 2003
2004/0225,347 Intravascular stent with increasing coating retaining capacity 34 2003
7052488 Implantable drug delivery device 92 2003
2005/0037,047 Medical devices comprising spray dried microparticles 102 2003
7713297 Drug-releasing stent with ceramic-containing layer 49 2003
2004/0039,438 Vascular and endoluminal stents with multi-layer coating including porous radiopaque layer 81 2003
* 2005/0060,021 Medical devices 66 2003
2005/0060,020 Covered stent with biologically active material 160 2003
2005/0070,990 Medical devices and methods of making same 84 2003
2004/0067,301 Medical device with porous surface for controlled drug release and method of making the same 51 2003
2005/0074,479 Using bucky paper as a therapeutic aid in medical applications 60 2003
2005/0087,520 Method and apparatus for selective ablation of coatings from medical devices 67 2003
7435256 Method and apparatus for controlled delivery of active substance 29 2003
2004/0181,276 Longitudinally flexible expandable stent 49 2003
2005/0131,522 Medical devices and methods of making the same 131 2003
2005/0149,102 Medical device systems 47 2003
2005/0159,805 Functional coatings and designs for medical implants 57 2004
2005/0163,954 Medical devices 81 2004
7041130 Stent for controlled release of drug 107 2004
2005/0129,727 Localized drug delivery using drug-loaded nanocapsules 81 2004
2005/0182,478 Laser shock peening of medical devices 50 2004
2005/0192,657 Medical devices 70 2004
2005/0196,518 Method and system for making a coated medical device 50 2004
2005/0015,142 Coated medical device and method for manufacturing the same 60 2004
2005/0203,606 Stent system for preventing restenosis 92 2004
2005/0208,100 Medical articles having regions with polyelectrolyte multilayer coatings for regulating drug release 104 2004
6861088 Method for spray-coating a medical device having a tubular wall such as a stent 166 2004
2005/0220,853 Controlled delivery of therapeutic agents from medical articles 63 2004
2004/0247,671 Solid drug formulation and device for storage and controlled delivery thereof 74 2004
2005/0266,039 Coated medical device and method for making the same 50 2004
2005/0266,040 Medical devices composed of porous metallic materials for delivering biologically active materials 56 2004
2006/0025,848 Medical device having a coating layer with structural elements therein and method of making the same 76 2004
* 2006/0034,884 Coated medical device having an increased coating surface area 36 2004
2006/0052,744 Method of coating a medical device using an electrowetting process, system for using the method, and device made by the method 81 2004
2006/0079,863 Medical devices coated with diamond-like carbon 38 2004
2005/0110,214 Composite stent with inner and outer stent elements and method of using the same 43 2004
2006/0088,566 Method of controlling drug release from a coated medical device through the use of nucleating agents 61 2004
2006/0088,567 Method of manufacturing a medical device having a porous coating thereon 52 2004
2006/0093,643 Medical device for delivering therapeutic agents over different time periods 60 2004
2006/0095,123 Stent for delivering a therapeutic agent having increased body tissue contact surface 41 2004
2006/0100,696 Medical devices and methods of making the same 56 2004
2006/0122,694 Medical devices and methods of making the same 60 2004
2006/0127,443 Medical devices having vapor deposited nanoporous coatings for controlled therapeutic agent delivery 85 2004
2006/0129,215 Medical devices having nanostructured regions for controlled tissue biocompatibility and drug delivery 82 2004
2006/0125,144 Stent and stent manufacturing methods 30 2004
2005/0197,687 Medical devices including metallic films and methods for making same 59 2004
2005/0197,689 Medical devices including metallic films and methods for making same 37 2004
2006/0153,729 Medical devices and methods of making the same 81 2005
2006/0171,985 Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility 55 2005
2006/0230,476 Polymeric/ceramic composite materials for use in medical devices 95 2005
2006/0222,844 Medical devices including composites 57 2005
2006/0233,941 Method of coating a medical device utilizing an ion-based thin film deposition technique, a system for coating a medical device, and a medical device produced by the method 53 2005
2005/0261,760 Medical devices and methods of making the same 89 2005
2006/0276,910 Endoprostheses 36 2005
2007/0038,176 Medical devices with machined layers for controlled communications with underlying regions 53 2005
7914809 Lubricious composites for medical devices 18 2005
2007/0048,452 Apparatus and method for field-injection electrostatic spray coating of medical devices 36 2005
2007/0072,978 Organic-inorganic hybrid particle material and polymer compositions containing same 30 2005
2006/0038,027 Apparatus and method for fine bore orifice spray coating of medical devices and pre-filming atomization 69 2005
2007/0110,888 Coated and imprinted medical devices and methods of making the same 51 2005
2007/0112,421 Medical device with a grooved surface 47 2005
2007/0134,288 Anti-adhesion agents for drug coatings 52 2005
2007/0154,513 Medical devices having multiple charged layers 49 2005
2007/0156,231 Bioerodible endoprostheses and methods of making the same 62 2006
2007/0190,104 Coating comprising an adhesive polymeric material for a medical device and method of preparing the same 55 2006
2007/0191,923 Medical balloons and methods of making the same 53 2006
2007/0191,931 Bioerodible endoprostheses and methods of making the same 53 2006
2007/0212,547 Method of powder coating medical devices 43 2006
2007/0224,244 Corrosion resistant coatings for biodegradable metallic implants 63 2006
2007/0224,235 Medical devices having nanoporous coatings for controlled therapeutic agent delivery 48 2006
2007/0224,116 Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents 49 2006
2007/0244,569 Endoprosthesis having a fiber meshwork disposed thereon 62 2006
2007/0254,091 System and method for electrostatic-assisted spray coating of a medical device 39 2006
2007/0264,303 Coating for medical devices comprising an inorganic or ceramic oxide and a therapeutic agent 53 2006
2007/0269,480 Medical devices having bioactive surfaces 31 2006
2008/0003,251 Coatings for medical devices comprising a therapeutic agent and a metallic material 57 2006
2008/0008,654 Medical devices having a temporary radiopaque coating 81 2006
2008/0058,921 IMPROVED ADHESION OF A POLYMERIC COATING OF A DRUG ELUTING STENT 48 2006
2008/0188,836 Medical devices having nanoporous coatings for controlled therapeutic agent delivery 56 2007
2008/0249,615 STENTS WITH CERAMIC DRUG RESERVOIR LAYER AND METHODS OF MAKING AND USING THE SAME 46 2007
2008/0249,600 STENTS WITH DRUG RESERVOIR LAYER AND METHODS OF MAKING AND USING THE SAME 48 2007
2008/0051,881 Medical devices comprising porous layers for the release of therapeutic agents 64 2007
2008/0275,543 Stent 29 2007
2008/0294,236 Endoprosthesis with Select Ceramic and Polymer Coatings 51 2007
2008/0294,246 Endoprosthesis with Select Ceramic Morphology 53 2007
2008/0050,415 Polymeric/ceramic composite materials for use in medical devices 39 2007
2008/0004,691 MEDICAL DEVICES WITH SELECTIVE COATING 54 2007
2009/0018,639 ENDOPROSTHESIS COATING 47 2007
2009/0018,647 ENDOPROSTHESIS COATING 48 2007
2009/0018,644 Boron-Enhanced Shape Memory Endoprostheses 32 2007
2008/0160,259 MEDICAL DEVICES AND METHODS OF MAKING THE SAME 58 2007
2009/0030,504 Medical devices comprising porous inorganic fibers for the release of therapeutic agents 56 2007
2009/0138,077 Articles having ceramic coated surfaces 61 2007
2007/0299,509 MEDICAL DEVICE WITH POROUS SURFACE FOR CONTROLLED DRUG RELEASE AND METHOD OF MAKING THE SAME 46 2007
2008/0071,355 Medical Devices with Drug-Eluting Coating 69 2007
2008/0071,348 Medical Devices 48 2007
2008/0071,349 Medical Devices 54 2007
2008/0071,350 ENDOPROSTHESES 59 2007
2008/0071,358 ENDOPROSTHESES 69 2007
2009/0076,588 Endoprosthesis 58 2007
2008/0071,351 ENDOPROSTHESIS WITH ADJUSTABLE SURFACE FEATURES 53 2007
2008/0071,352 BIOERODIBLE ENDOPROSTHESIS WITH BIOSTABLE INORGANIC LAYERS 50 2007
2008/0071,353 ENDOPROSTHESIS CONTAINING MAGNETIC INDUCTION PARTICLES 51 2007
2008/0086,201 MAGNETIZED BIOERODIBLE ENDOPROSTHESIS 49 2007
2009/0076,595 Medical devices having bioerodable layers for the release of therapeutic agents 42 2007
2008/0097,577 MEDICAL DEVICE HYDROGEN SURFACE TREATMENT BY ELECTROCHEMICAL REDUCTION 51 2007
2008/0147,177 ENDOPROSTHESIS WITH COATINGS 59 2007
2008/0145,400 Ion Bombardment of Medical Devices 47 2007
2009/0118,809 ENDOPROSTHESIS WITH POROUS RESERVOIR AND NON-POLYMER DIFFUSION LAYER 47 2007
2009/0118,812 ENDOPROSTHESIS COATING 47 2007
2009/0118,813 NANO-PATTERNED IMPLANT SURFACES 49 2007
2009/0118,814 ENDOPROSTHESIS COATING 47 2007
2009/0118,815 STENT 50 2007
2009/0118,818 ENDOPROSTHESIS WITH COATING 46 2007
2009/0118,820 DEFORMABLE UNDERLAYER FOR STENT 46 2007
2009/0118,821 ENDOPROSTHESIS WITH POROUS RESERVOIR AND NON-POLYMER DIFFUSION LAYER 49 2007
2009/0118,822 STENT WITH EMBEDDED MATERIAL 49 2007
2009/0118,823 ENDOPROSTHESIS WITH POROUS RESERVOIR 49 2007
2009/0123,521 Medical devices having coatings for controlled therapeutic agent delivery 65 2007
7749264 Medical devices and methods of making the same 47 2008
2008/0241,218 Coated medical devices for abluminal drug delivery 52 2008
2008/0243,231 Medical device with a porous surface for delivery of a therapeutic agent 62 2008
2009/0018,642 Methods to improve the stability of celluar adhesive proteins and peptides 28 2008
2008/0255,657 STENT WITH UNCONNECTED STENT SEGMENTS 27 2008
2009/0123,517 MEDICAL DEVICES FOR RELEASING THERAPEUTIC AGENT AND METHODS OF MAKING THE SAME 48 2008
2009/0281,613 Endoprostheses 48 2008
2009/0287,301 Coating for medical implants 47 2008
2009/0306,765 Bioerodible Endoprosthesis 48 2008
2009/0012,603 IMPLANTABLE MEDICAL DEVICES HAVING ADJUSTABLE PORE VOLUME AND METHODS FOR MAKING THE SAME 28 2008
2009/0149,942 ENDOPROSTHESIS HAVING A NON-FOULING SURFACE 47 2008
2009/0028,785 MEDICAL DEVICES WITH COATINGS FOR DELIVERY OF A THERAPEUTIC AGENT 48 2008
2009/0157,172 STENTS WITH POLYMER-FREE COATINGS FOR DELIVERING A THERAPEUTIC AGENT 58 2008
2010/0030,326 Bioerodible Endoprosthesis 47 2008
2009/0157,165 Degradable Endoprosthesis 48 2008
2009/0157,166 Medical Devices Having Porous Component For Controlled Diffusion 36 2008
2010/0008,970 Drug-Eluting Endoprosthesis 51 2008
2009/0192,593 Stent for Delivery a Therapeutic Agent from a Side Surface of a Stent StSrut 46 2009
2009/0202,610 Medical Implants With Polysaccharide Drug Eluting Coatings 51 2009
2009/0259,300 Medical Devices With an Interlocking Coating and Methods of Making the Same 48 2009
2009/0264,975 MEDICAL DEVICES HAVING A COATING OF INORGANIC MATERIAL 37 2009
2009/0319,032 ENDOPROSTHESIS COATING 27 2009
2010/0028,403 MEDICAL DEVICES FOR THERAPEUTIC AGENT DELIVERY 20 2009
2010/0057,197 MEDICAL DEVICES HAVING INORGANIC COATINGS FOR THERAPEUTIC AGENT DELIVERY 70 2009
2010/0070,022 LAYER BY LAYER MANUFACTURING OF A STENT 44 2009
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6395325 Porous membranes 91 2000
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2002/0065,553 Method for manufacturing a medical device having a coated portion by laser ablation 166 2001
6652575 Stent with smooth ends 142 2001
6869443 Biodegradable drug delivery vascular stent 152 2002
2004/0086,674 Laser sintering process and devices made therefrom 47 2002
2004/0098,119 Stent with smooth ends 53 2003
2006/0127,442 Use of supercritical fluids to incorporate biologically active agents into nanoporous medical articles 40 2004
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2007/0191,943 Integration Of Therapeutic Agent Into A Bioerodible Medical Device 57 2006
2008/0057,103 METHODS OF USING MEDICAL DEVICES FOR CONTROLLED DRUG RELEASE 38 2007
 
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2005/0055,085 Implantable medical devices having recesses 58 2003
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2007/0065,418 Method and device for cellular therapy 48 2006
2007/0219,626 Stents made of biodegradable and non-biodegradable materials 55 2007
2007/0191,928 Angioplasty stents 47 2007
2008/0288,048 STENTS FOR ANGIOPLASTY 46 2007
 
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2004/0000,540 Laser texturing of surfaces for biomedical implants 54 2003
2005/0211,680 Systems and methods for laser texturing of surfaces of a substrate 108 2005
 
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2004/0030,377 Medicated polymer-coated stent assembly 97 2003
7244272 Vascular prosthesis and method for production thereof 62 2005
 
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6932930 Intraluminal prostheses having polymeric material with selectively modified crystallinity and methods of making same 92 2003
 
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The Kendall Company (1)
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5873904 Silver implantable medical device 916 1997
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6174329 Protective coating for a stent with intermediate radiopaque coating 250 1996
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5843172 Porous medicated stent 439 1997
6240616 Method of manufacturing a medicated porous metal prosthesis 502 1997
6287628 Porous prosthesis and a method of depositing substances into the pores 381 1999
6251136 Method of layering a three-coated stent using pharmacological and polymeric agents 374 1999
6471721 Vascular stent having increased radiopacity and method for making same 142 1999
6527801 Biodegradable drug delivery material for stent 362 2000
6395326 Apparatus and method for depositing a coating onto a surface of a prosthesis 550 2000
6585765 Implantable device having substances impregnated therein and a method of impregnating the same 290 2000
6254632 Implantable medical device having protruding surface structures for drug delivery and cover attachment 535 2000
6716444 Barriers for polymer-coated implantable medical devices and methods for making the same 316 2000
6805898 Surface features of an implantable medical device 224 2000
6506437 Methods of coating an implantable device having depots formed in a surface thereof 397 2000
6558733 Method for etching a micropatterned microdepot prosthesis 324 2000
6663664 Self-expanding stent with time variable radial force 128 2000
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6663662 Diffusion barrier layer for implantable devices 317 2000
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2001/0014,717 Coating for implantable devices and a method of forming the same 233 2000
2002/0123,801 Diffusion barrier layer for implantable devices 210 2000
6635082 Radiopaque stent 103 2000
6641607 Double tube stent 110 2000
2002/0087,123 Adhesion of heparin-containing coatings to blood-contacting surfaces of medical devices 202 2001
6544582 Method and apparatus for coating an implantable device 277 2001
6780424 Controlled morphologies in polymer drug for release of drugs from polymer films 126 2001
6673105 Metal prosthesis coated with expandable ePTFE 99 2001
6764505 Variable surface area stent 364 2001
6712845 Coating for a stent and a method of forming the same 326 2001
2002/0155,212 Coating for a stent and a method of forming the same 253 2001
6660034 Stent for increasing blood flow to ischemic tissues and a method of using the same 286 2001
6656506 Microparticle coated medical device 235 2001
2002/0183,581 Radiation or drug delivery source with activity gradient to minimize edge effects 230 2001
6712844 MRI compatible stent 90 2001
2003/0004,563 Polymeric stent suitable for imaging by MRI and fluoroscopy 132 2001
6979346 System and method for improved stent retention 90 2001
6753071 Rate-reducing membrane for release of an agent 325 2001
2003/0104,028 Rate limiting barriers for implantable devices and methods for fabrication thereof 80 2001
6866805 Hybrid intravascular stent 129 2001
6616765 Apparatus and method for depositing a coating onto a surface of a prosthesis 254 2002
6723120 Medicated porous metal prosthesis 240 2002
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7169178 Stent with drug coating 92 2002
6908624 Coating for implantable devices and a method of forming the same 148 2002
6725901 Methods of manufacture of fully consolidated or porous medical devices 72 2002
6896697 Intravascular stent 91 2002
7105018 Drug-eluting stent cover and method of use 87 2002
7163715 Spray processing of porous medical devices 125 2002
2004/0224,001 Stent coatings comprising hydrophilic additives 168 2003
6846323 Intravascular stent 194 2003
2004/0230,293 INTRAVASCULAR STENT 120 2003
2005/0021,127 Porous glass fused onto stent for drug retention 71 2003
7056591 Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same 87 2003
7247166 Intravascular stent with extendible end rings 31 2003
7198675 Stent mandrel fixture and method for selectively coating surfaces of a stent 78 2003
2005/0069,630 Stent mandrel fixture and method for selectively coating surfaces of a stent 98 2003
6953560 Barriers for polymer-coated implantable medical devices and methods for making the same 82 2003
7563324 System and method for coating an implantable medical device 61 2003
2004/0234,737 Rate-reducing membrane for release of an agent 53 2004
7229471 Compositions containing fast-leaching plasticizers for improved performance of medical devices 99 2004
2006/0136,048 Abluminal, multilayer coating constructs for drug-delivery stents 84 2004
7638156 Apparatus and method for selectively coating a medical article 31 2005
2007/0148,251 Nanoparticle releasing medical devices 80 2005
2007/0003,589 Coatings for implantable medical devices containing attractants for endothelial cells 67 2006
7416558 Drug-eluting stent cover and method of use 51 2006
2007/0032,858 Stent with drug coating 51 2006
2007/0036,905 Method and apparatus for spray processing of porous medical devices 59 2006
2007/0055,349 Stent with drug coating 48 2006
2007/0055,354 Stent with drug coating 46 2006
2007/0059,435 Stent with drug coating 46 2006
 
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2005/0278,021 Coated medical device 129 2005
 
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* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
BOSTON SCIENTIFIC SCIMED, INC. (2)
* 8663317 Intraluminar perforated radially expandable drug delivery prosthesis and a method for the production thereof 0 2012
* 2013/0004,650 Intraluminar perforated radially expandable drug delivery prosthesis and a method for the production thereof 2 2012
* Cited By Examiner

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