Expansion of stem/progenitor cells by inhibition of enzymatic reactions catalyzed by the Sir2 family of enzymes
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United States of America Patent
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May 29, 2012
Grant Date -
Jan 1, 2009
app pub date -
Jul 14, 2005
filing date -
Jul 14, 2004
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Abstract
Provided are ex vivo and in vivo methods of expanding renewable stem cells using agents capable of down-regulating Sir2 protein activity and/or expression, expanded populations of renewable stem cells, and uses thereof.
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