Methods of monitoring cellular death using low frequency ultrasound
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United States of America Patent
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Jun 5, 2012
Grant Date -
Jul 19, 2007
app pub date -
Jun 15, 2006
filing date -
Jun 16, 2005
priority date (Note) -
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Abstract
A method of detecting cellular damage within a subject comprises transmitting low frequency ultrasound (20 MHz or below) into a selected site within the subject wherein the selected site has been exposed to a stress capable of causing cellular death at the selected site. At least a portion of ultrasound backscattered from the ultrasound transmitted into the selected site is received. The received backscattered ultrasound is compared to a control backscatter measurement. An increase or a decrease in intensity or spectral slope of the received backscattered ultrasound when compared to the control backscatter measurement indicates cellular death or damage at the selected site within the subject.
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