Live attenuated rotavirus vaccine for oral administration
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United States of America Patent
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Jun 5, 2012
Grant Date -
Jul 10, 2008
app pub date -
Feb 15, 2006
filing date -
Feb 17, 2005
priority date (Note) -
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Abstract
This invention provides liquid rotavirus formulations that are suitable for oral administration to human infants. In particular, the invention provides pharmaceutical compositions and vaccines, comprising a rotavirus antigen, a sugar and a carboxylate, wherein said formulation has a pH of between pH 5.0 and pH 8.0 and comprises no phosphate or less than 5 mM phosphate. The invention also provides methods of preparing said rotavirus formulations and use thereof in the prevention or treatment or rotavirus associated diseases in humans.
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Family
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