Binding domain-immunoglobulin fusion proteins
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United States of America Patent
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Jun 12, 2012
Grant Date -
Apr 21, 2011
app pub date -
Oct 8, 2010
filing date -
Jan 17, 2001
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Abstract
The invention relates to novel binding domain-immunoglobulin fusion proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, a hinge region polypeptide having either zero or one cysteine residue, and immunoglobulin CH2 and CH3 domains, and that are capable of ADCC and/or CDC while occurring predominantly as monomeric polypeptides. The fusion proteins can be recombinantly produced at high expression levels. Also provided are related compositions and methods, including immunotherapeutic applications.
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