Biomarkers for amyotrophic lateral sclerosis
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United States of America Patent
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Jun 19, 2012
Grant Date -
May 5, 2011
app pub date -
Dec 1, 2010
filing date -
Oct 23, 2003
priority date (Note) -
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Abstract
The invention provides a method for diagnosing amyotrophic lateral sclerosis (ALS) in a subject, a method for assessing the effectiveness of a drug in treating ALS, and a method for determining the site of onset of ALS in a subject. Each method comprises (a) obtaining a sample from the subject, (b) analyzing the proteins in the sample by mass spectroscopy, and (c) determining a mass spectral profile for the sample. In some embodiments, the method comprises comparing the mass spectral profile of the sample to the mass spectral profile of a positive or a negative standard.
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