Inhibition of cholera toxins by galatooligosaccharides (GOS)

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United States of America Patent

PATENT NO 8202842
APP PUB NO 20100069322A1
SERIAL NO

12443565

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Abstract

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The invention relates to nutritional and pharmaceutical compositions comprising non-digestible galactooligosaccharides (GOS) and uses thereof. In particular, it relates to the use of GOS species in preventing or treating disease caused by bacterial toxins. Provided is the use of GOS having a polymerization degree of 5 or higher, preferably 6 or higher, for the manufacture of a nutritional or pharmaceutical composition for the treatment or prevention of an acute or chronic disease associated with or caused by the adhesion and/or uptake of a cholera toxin family member. Also provided is a method for providing a GOS fraction capable of inhibiting cholera toxin (Ctx) binding to GM1 and fractions obtainable thereby.

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FRIESLAND BRANDS B V3818 LE AMERSFOORT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
De, Slegte Jaap Doetinchem, NL 1 14
Klarenbeek, Gijsbertus Ommen, NL 4 17
Sinclair, Haydn Robert Camerton Bath and South East Somerset, GB 1 14

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