Nanoloom for controlling polymer assembly

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United States of America Patent

PATENT NO 8206773
APP PUB NO 20090148601A1
SERIAL NO

11992611

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Systems, devices, and methods are provided for assembling polymer-forming molecular components such that highly-structured arrays of polymer strands, such as collagen fibrils, are formed without the need for cells. A polymer nanoloom is designed to control the self-assembly of monomers into fibrils and related tissue constructs including ligament, tendon, cartilage, and bone. A nanoloom system comprises a polymer printhead, a temperature controller, and a movable substrate for polymer printing. A polymer printhead contains one or more nanoreactors that can control the assembly of collagen fibrils or other polymers on a nanoscale. Methods are provided for temperature-driven, enzyme-driven, and cholesteric assembly of collagen or other polymers into two- or three-dimensional tissue constructs.

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Patent Owner(s)

Patent OwnerAddress
NORTHEASTERN UNIVERSITYC/O THE CENTER FOR RESEARCH INNOVATION 360 HUNTINGTON AVENUE BOSTON MA 02115

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Burkey, Daniel Waltham, US 2 1
Kowalski, Gregory J Beverly, US 18 135
Ruberti, Jeffrey W Lexington, US 24 791

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