Methods and devices for epithelial protection during photodynamic therapy
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United States of America Patent
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Jun 26, 2012
Grant Date -
Apr 22, 2010
app pub date -
Dec 21, 2009
filing date -
Apr 15, 2003
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Methods for preventing damage to the epidermis during PDT induced using a pre-photosensitizing agent are provided. The methods of the present invention utilize spatial confinement to control formation of a photoactive species from a topically-applied pre-photosensitizing agent. In one embodiment, thermal inhibition is used to prevent the metabolism of a pre-photosensitizing agent in epithelial tissue surrounding a treatment site. In another embodiment, a chemical inhibitor can be applied to the epithelial tissue to inhibit the conversion of a pre-photosensitizing agent into a phototoxic species.
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International Classification(s)
- A61K:PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOS....
- A01N:PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLA....
- C07D:HETEROCYCLIC COMPOUNDS
- C07C:ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07B:GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS TH....
- A61B:DIAGNOSIS; SURGERY; IDENTIFICATION
- A61N:ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY;....
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