Trypsin-like serine protease inhibitors, and their preparation and use
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United States of America Patent
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Jun 26, 2012
Grant Date -
Jan 28, 2010
app pub date -
Apr 24, 2009
filing date -
Oct 24, 2006
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Abstract
The invention relates to inhibitors of trypsin-like serine proteases of the general formula (I) which, as well as plasmin, also inhibit plasma kallikrien, and to their preparation and use as medicaments, preferably for treatment of blood loss, especially in the case of hyperfibrinolytic states, in organ transplants or heart surgery interventions, in particular with a cardiopulmonary bypass, or as a constituent of a fibrin adhesive.
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