Hepatitis C virus non structural fusion protein

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 8211444
APP PUB NO 20090186046A1
SERIAL NO

12282146

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Abstract

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The present invention relates to an isolated fusion protein comprising at least three NS polypeptides originating from a hepatitis C virus which are configured in said fusion protein in an order which is distinct of the order in which they appear in the native configuration. The present invention also relates to a nucleic acid molecule encoding such a fusion protein and a vector comprising such a nucleic acid molecule. The present invention also provides infectious viral particles and host cells comprising such a nucleic acid molecule or such a vector. The present invention also relates to a method for recombinantly producing such a fusion protein. Finally, the present invention also provides a pharmaceutical composition comprising such a fusion protein, a nucleic acid molecule, a vector, infectious viral particles and a host cell as well as the therapeutic use thereof for treating or preventing HCV infections, HCV-associated diseases and pathologic conditions as well as a method of inducing or stimulating an immune response against HCV in a host organism.

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Patent Owner(s)

  • TRANSGENE S.A.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chatel, Laurence Jozier, FR 1 0
Fournillier, Ann Lyon, FR 1 0
Inchauspe, Genevieve Lyon, FR 20 49
Penin, Francois Decines, FR 6 10

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