Unoccluded topical oxybutynin gel composition and methods for transdermal oxybutynin therapy

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United States of America Patent

PATENT NO 8241662
SERIAL NO

11645076

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder. In some aspects, the composition may be presented in the form of an unoccluded or free form topically administered gel.

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Patent Owner(s)

  • ALLERGAN SALES, LLC;WATSON LABORATORIES, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ebert, Charles D Salt Lake City, US 42 2721
Sanders, Steven W Salt Lake City, US 14 98

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