Devices and methods for analyzing biomolecules and probes bound thereto
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United States of America Patent
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Aug 21, 2012
Grant Date -
Dec 9, 2010
app pub date -
May 28, 2010
filing date -
May 28, 2009
priority date (Note) -
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Abstract
Devices and methods for detecting the length of analytes and/or sequencing analytes are provided in which two or more electrical signals are obtained as an analyte traverses a nanopore or fluidic channel. Detection of the relative position of probes hybridized to a biomolecule and/or the length of the analyte (e.g., a biomolecule) rely on detection events to determine a distance associated with the biomolecule. Multiple signals may be obtained (e.g., as functions of time) corresponding to a plurality of detector volumes at known locations along a fluidic channel through which the biomolecule passes, and the distances may be determined from the multiple signals.
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