Antagonists of IL-6 to prevent or treat thrombosis
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United States of America Patent
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Aug 28, 2012
Grant Date -
Nov 26, 2009
app pub date -
Nov 25, 2008
filing date -
May 21, 2007
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Abstract
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat thrombosis in diseases associated with abnormal blood coagulation or fibrinolysis. In preferred embodiments these patients will comprise those exhibiting elevated D-dimer or other coagulation cascade related proteins and optionally will further exhibit elevated C reactive protein prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, et al.
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