Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
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United States of America Patent
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Sep 4, 2012
Grant Date -
Mar 18, 2010
app pub date -
Sep 15, 2008
filing date -
Sep 15, 2008
priority date (Note) -
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Abstract
A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with an amphiphilic polymer coating comprising a therapeutic agent and an amphiphilic polymer or co-polymer. The medical disposable device is inserted into a body lumen, and expanded to contact the amphiphilic polymer coating against the body lumen. The total solubility of the polymer or co-polymer in vivo prevents any embolic hazard associated with the amphiphilic polymer coating.
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