Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy
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United States of America Patent
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Sep 18, 2012
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Oct 22, 2004
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Oct 22, 2003
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Abstract
Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is transformed into a first haploid cell; and a second expression vector is transformed into a second haploid cell. The transformed haploid cells, each individually synthesizing a non-identical polypeptide, are identified and then genetically crossed or fused. The resulting diploid strains are utilized to produce and secrete fully assembled and biologically functional hetero-multimeric protein.
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