Method for the purification of mycophenolate mofetil
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United States of America Patent
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Sep 25, 2012
Grant Date -
Jul 29, 2010
app pub date -
Jun 24, 2008
filing date -
Jun 27, 2007
priority date (Note) -
Expired
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Abstract
The present invention provides a method for the preparation of mycophenolate mofetil wherein mycophenolic acid or an amine salt of mycophenolic acid is esterified with 2-morpholinoethanol, the resulting mixture is extracted into water at a pH-value between 1.0 and 3.0, and mycophenolate mofetil is back-extracted in a water-immiscible solvent at a pH-value between 3.0 and 5.0.
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