Mucosal vascular addressins and uses thereof
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United States of America Patent
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Oct 2, 2012
Grant Date -
Aug 2, 2007
app pub date -
Apr 3, 2007
filing date -
Sep 1, 1995
priority date (Note) -
Expired
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Abstract
The present invention relates to isolated antibodies and antigen-binding fragments thereof that bind naturally occurring human MAdCAM, wherein said naturally occurring human MAdCAM comprises a polypeptide with at least 90% sequence identity to SEQ ID NO:2 or SEQ ID NO:4, said naturally occurring human MAdCAM binds α4β7, and wherein said isolated antibodies and antigen-binding fragments thereof inhibit binding of said naturally occurring human MAdCAM to human α4β7, and wherein said antibody inhibits adhesion of RPMI 8866 cells to cells that express said human MAdCAM.
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