Functionalization of silk material by avidin-biotin interaction

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United States of America Patent

PATENT NO 8293486
APP PUB NO 20120129255A1
SERIAL NO

13381687

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Abstract

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The present invention provides for compositions and methods of linking silk fibroin to active agents through the specific interaction between avidin and biotin, providing for functionalization of silk-based protein biomaterials. An avidin- or biotin-modified silk is a biomaterial platform for functionalization with a variety of correspondingly linked active agents, such as antibodies and growth factors. A variety of functionalized silk materials, such as silk hydrogel, silk micro/nanoparticles and silk films, can be prepared by the methods of the present invention. The functionalization strategies of the present invention are relatively easy, fast and feasible, and are thus useful in many biomedical applications.

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Patent Owner(s)

Patent OwnerAddress
TRUSTEES OF TUFTS COLLEGEBALLOU HALL MEDFORD MA 02155

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kaplan, David L Concord, US 273 9748
Serban, Monica A Melrose, US 14 96
Wang, Xiaoqin Winchester, US 41 548

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