Stable and sterile tissue adhesive composition with a controlled high viscosity
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United States of America Patent
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Oct 23, 2012
Grant Date -
Dec 24, 2009
app pub date -
Jun 20, 2008
filing date -
Jun 20, 2008
priority date (Note) -
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Abstract
A stable and sterile adhesive composition with a controlled level of high viscosity is disclosed in the present invention. Adhesive compositions with different ranges of viscosity could be prepared by heating the adhesive monomer composition at mild temperature in the presence of pluronic polymer. The viscosity of the adhesive composition is able to be controlled to any desired level. A method of stabilizing the adhesive composition with a desired level of high viscosity is provided by using the combination of free radical and acid stabilizers. Methods for packaging, sterilizing and applying the adhesive in the medical field are also provided.
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