One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
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United States of America Patent
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Oct 23, 2012
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app pub date -
Jun 23, 2005
filing date -
Jun 25, 2004
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Abstract
A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7 and C-10 positions and attaching a side chain at the C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and taxane intermediates.
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