Electroporation to deliver chemotherapeutics and enhance tumor regression

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 8298222
APP PUB NO 20090326436A1
SERIAL NO

12430336

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Abstract

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A method is disclosed for disrupting capillary blood flow and trapping materials such as chemotherapeutic agents in undesirable tissue, including cells of a cancerous or non-cancerous tumor. The method involves the placement of electrodes into or near the vicinity of capillary vessels supplying blood to capillaries in the undesirable tissue, and application of electrical pulses causing capillary blood flow disruption. In some cases, the electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body's immune system. The process may further comprise monitoring blood flow and/or infusion of a material such as a chemotherapeutic agent or marker into the blood.

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Patent Owner(s)

Patent OwnerAddress
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA1111 FRANKLIN STREET TWELFTH FLOOR OAKLAND CA 94607-5200

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Edd, Jon Berkeley, US 5 979
Horowitz, Liana Givataaim, IL 4 661
Rubinsky, Boris Givataaim, IL 114 9708

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