Methods and compositions for silencing genes without inducing toxicity
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United States of America Patent
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Oct 30, 2012
Grant Date -
May 28, 2009
app pub date -
Sep 24, 2008
filing date -
Apr 26, 2002
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Abstract
The present invention provides methods of post-transcriptional gene silencing which involve the use of a first dsRNA having substantial sequence identity to a target nucleic acid and a short, second dsRNA which inhibits dsRNA-mediated toxicity. These methods can be used to prevent or treat a disease or infection by silencing a gene associated with the disease or infection. The invention also provides methods for identifying nucleic acid sequences that modulate a detectable phenotype, including the function of a cell, the expression of a gene, or the biological activity of a target polypeptide.
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