Method and system for standardizing microscope instruments

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United States of America Patent

PATENT NO 8314931
APP PUB NO 20110299070A1
SERIAL NO

13209068

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Methods and apparatus for standardizing quantitative measurements from a microscope system. The process includes a calibration procedure whereby an image of a calibration slide is obtained through the optics of the microscope system. The calibration slide produces a standard response, which can be used to determine a machine intrinsic factor for the particular system. The machine intrinsic factor can be stored for later reference. In use, images are acquired of a target sample and of the excitation light source. The excitation light source sample is obtained using a calibration instrument configured to sample intensity. The calibration instrument has an associated correction factor to compensate its performance to a universally standardized calibration instrument. The machine intrinsic factor, sampled intensity, and calibration instrument correction factor are usable to compensate a quantitative measurement of the target sample in order to normalize the results for comparison with other microscope systems.

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Patent Owner(s)

  • NOVARTIS AG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Christiansen, Jason Glastonbury, US 19 183
Pinard, Robert Andover, US 36 229
Tedeschi, Gregory R Cromwell, US 13 176
Zerkowski, Maciej P Old Lyme, US 7 118

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