Attenuated bacteria useful in vaccines

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United States of America Patent

PATENT NO 8318148
SERIAL NO

13073999

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Abstract

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The invention provides strains of bacteria, especially enterotoxigenic E. coli, attenuated by mutations in the genes encoding enterotoxins (LT, ST, EAST1) and optionally further attenuated by deletion of additional chromosomal genes. In addition the invention provides strains of attenuated bacteria expressing immunogenic but non-toxic variants of one or more of these enterotoxins. These bacteria are useful as a vaccine against diarrhoeal disease.

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Patent Owner(s)

Patent OwnerAddress
ACAMBIS RESEARCH LIMITEDPETERHOUSE TECHNOLOGY PARK 100 FULBOURN ROAD CAMBRIDGE CB1 9PT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beavis, Juliet Claire Cambridge, GB 4 23
Darsley, Michael James Cambridge, GB 4 23
Greenwood, Judith Cambridge, GB 5 25
Stephens, Jonathan Clive Cambridge, GB 5 35
Turner, Arthur Keith Cambridge, GB 11 44

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