Anti A beta antibody formulation
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United States of America Patent
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Nov 27, 2012
Grant Date -
Jul 1, 2010
app pub date -
Dec 14, 2009
filing date -
Jan 28, 2005
priority date (Note) -
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status (Latency Note)
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Abstract
The present invention provides formulations for maintaining the stability of Aβ binding polypeptides, for example, Aβ antibodies. Exemplary formulations include a tonicity agent such as mannitol and a buffering agent or amino acid such as histidine. Other exemplary formulations include an antioxidant in a sufficient amount as to inhibit by-product formation, for example, the formation of high molecular weight polypeptide aggregates, low molecular weight polypeptide degradation fragments, and mixtures thereof. The formulations of the invention optionally comprise a tonicity agent, such as mannitol, and a buffering agent or amino acid such as histidine. The formulations are suitable for several different routes of administration.
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