Method for determining the amount of conjugated taxane in polyglut acid-taxane conjugates
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United States of America Patent
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Nov 27, 2012
Grant Date -
Jun 17, 2010
app pub date -
Mar 5, 2008
filing date -
Mar 6, 2007
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Abstract
The invention relates to a method for determining the amount of conjugated taxane, in particular paclitaxel, in a PGA-taxane conjugate said method comprising: a) reacting the PGA-taxane conjugate with a compound formula (I): R1R2N—NH2 (I), wherein R1 and R2 are as defined in the description; to give a unbound taxane and a PGA hydrazide and b) determining the amount of unbound taxane.
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