Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy
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United States of America Patent
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Nov 27, 2012
Grant Date -
Jul 21, 2011
app pub date -
Jan 13, 2011
filing date -
Oct 14, 2005
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Abstract
Provided is a method of treating cancer in a subject by inhibiting expression of PAX2. An example of a cancer treated by the present method is prostate cancer. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.
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