miRNA triplex formations for the downregulation of viral replication
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United States of America Patent
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Dec 4, 2012
Grant Date -
Feb 25, 2010
app pub date -
Jul 30, 2009
filing date -
Aug 1, 2008
priority date (Note) -
Expired
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Abstract
As discovered herein, using miRNAs having high homology with both HIV-1 and a co-infecting virus such as HHV-6, HHV-7, or GVB-C, one can inhibit viral replication, more particularly HIV-1 replication using such mutually homologous miRNAs that give rise to the creation of stable triplex formations effective in the downregulation and/or inhibition of viral replication.
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