Administration of exogenous miRNA or siRNA
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United States of America Patent
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Dec 4, 2012
Grant Date -
Apr 21, 2011
app pub date -
Oct 19, 2010
filing date -
Oct 19, 2009
priority date (Note) -
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Abstract
Certain genes controlled by endogenous miRNA are actually upregulated upon the transfection of exogenous mi/siRNA. Based on this, methods of determining whether administration of mi/siRNA will have a deleterious effect by upregulating certain genes are provided. Comparison of sequences of exogenous mi/siRNA allows selection of exogenous miRNA to be administered to cell to enhance or limit this affect, and therefore to control unwanted disregulation, or to upregulate an endogenous miRNA-regulated gene of interest.
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