Oxocarbonamide peptide nucleic acids and methods of using same
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United States of America Patent
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Dec 4, 2012
Grant Date -
Nov 29, 2012
app pub date -
Nov 29, 2007
filing date -
Dec 4, 2006
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Abstract
The present invention concerns oxocarbonamide peptide nucleic acids (OxoPNAs). OxoPNAs provide increased stability, sensitivity, and specificity as compared to their natural DNA and RNA counterparts. The OxoPNA molecules of the present invention may be employed in a wide range of applications, particularly in applications involving hybridization. For example, OxoPNA probes may be employed for the detection and functional analysis of nucleic acid molecules, including miRNAs and other non-coding RNAs.
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