MEMS interstitial prothrombin time test
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United States of America Patent
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Dec 11, 2012
Grant Date -
Apr 9, 2009
app pub date -
Aug 11, 2008
filing date -
Aug 10, 2007
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method of determining a prothrombin time is disclosed. A mediator is applied to a stratum corneum. The stratum corneum is penetrated to allow the mediator to enter a region containing interstitial fluid and interact with at least one capillary, causing blood and/or blood components to leak from the at least one capillary into the region containing interstitial fluid. A characteristic affected by the blood and/or blood components is measured in the region containing interstitial fluid which correlates to the prothrombin time. A system for measuring prothrombin time is also disclosed. The system has a mediator, one or more microneedles, and a processor directly or indirectly coupled to the one or more microneedles and configured to determine a coagulation change in blood or blood components in a region around the one or more microneedles after the one or more microneedles penetrate a stratum corneum.
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