Process for manufacturing vaccines
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United States of America Patent
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Dec 11, 2012
Grant Date -
Aug 26, 2010
app pub date -
Jun 23, 2006
filing date -
Jun 27, 2005
priority date (Note) -
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Abstract
The present application discloses an improved method for conducting saccharide-protein conjugation reactions using carbodiimide condensation chemistry. Depending on the nature of the saccharide or protein carrier involved, the quality of the conjugate may be improved by adding one of the reaction components slowly to the reaction mixture. Immunogenic compositions are further provided comprising the saccharide-protein conjugates made by the methods disclosed.
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