Antisense antiviral compound and method for treating picornavirus infection
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United States of America Patent
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Dec 11, 2012
Grant Date -
Jun 7, 2007
app pub date -
Sep 8, 2006
filing date -
Sep 8, 2005
priority date (Note) -
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Abstract
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Picornaviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of Enterovirus and/or Rhinovirus infection in a mammal. The antisense antiviral compounds are substantially uncharged, including partially positively charged, morpholino oligonucleotides have a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with viral RNA sequences within a 32 nucleotide region of the viral 5′ untranslated region identified by SEQ ID NO:4.
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