Poly TLR antagonist
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United States of America Patent
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Dec 18, 2012
Grant Date -
Mar 11, 2010
app pub date -
Nov 21, 2007
filing date -
Nov 23, 2006
priority date (Note) -
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Abstract
Mycobacterium w or its components are found to have poly TLR antagonistic activity to induced TLRs by varieties of TLR ligands. The induced TLR against which inhibitory effect is seen includes TLR 3, 4, 5, 6, 7, 8, 9. They also display antagonistic activities to effects of TLR ligands. They are also useful in management of diseases wherein TLRs are over expressed, like sepsis, multiple sclerosis, optic neuritis, Chronic obstructive pulmonary diseases multiple myeloma etc.
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