N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase
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United States of America Patent
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Dec 18, 2012
Grant Date -
Dec 30, 2010
app pub date -
Feb 19, 2008
filing date -
Feb 23, 2007
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Expired
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Abstract
Novel substituted amide inhibitors, their use in therapy, pharmaceutical compositions comprising the compounds, the use of said compounds in the manufacture of medicaments, and therapeutic methods comprising the administration of said compounds are described. The present compounds modulate the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, such as the metabolic syndrome.
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