Modified macromolecule
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United States of America Patent
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Dec 25, 2012
Grant Date -
Dec 31, 2009
app pub date -
May 15, 2006
filing date -
Jan 20, 2006
priority date (Note) -
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Abstract
The present invention relates to a macromolecule having a controlled terminal group stoichiometry, the macromolecule including a surface layer, at least one subsurface layer and at least two terminal groups including: a first terminal group which is a residue of a pharmaceutically active agent, a derivative thereof or precursor therefor; and a second terminal group selected to modify the pharmacokinetics of the pharmaceutically active agent and/or macromolecule, wherein terminal group stoichiometry refers to the number and type of terminal groups.
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