Compositions for the treatment of CNS-related conditions
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United States of America Patent
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Dec 25, 2012
Grant Date -
Oct 18, 2012
app pub date -
Jun 28, 2012
filing date -
Nov 23, 2004
priority date (Note) -
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Abstract
The invention provides compositions comprising extended release memantine in combination with immediate release donepezil to a subject. Memantine in an extended release form containing 22.5 to 30 mg memantine or a pharmaceutically acceptable salt thereof in combination with donepezil achieves particular pharmacokinetic criteria such as change in plasma concentration of memantine over time and ratio of maximum memantine plasma concentration to mean memantine plasma concentration.
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