Polymer conjugates of opioid antagonists

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United States of America Patent

PATENT NO 8349307
APP PUB NO 20100105715A1
SERIAL NO

12574335

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Abstract

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The invention provides polymer conjugates of opioid antagonists comprising a polymer, such as poly(ethylene glycol), covalently attached to an opioid antagonist. The linkage between the polymer and the opioid antagonist is preferably hydrolytically stable. The invention also includes a method of treating one or more side effects associated with the use of opioid analgesics, such as constipation, nausea, or pruritus, by administering a polymer conjugate of the invention.

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Patent OwnerAddress
NEKTAR THERAPEUTICSSAN FRANCISCO CA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bentley, Michael David Huntsville, US 77 2412
Cheng, Lin Huntsville, US 189 1423
Roberts, Michael James Williamsburg, US 14 425
Shen, Xiaoming Madison, US 76 2047

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