Antibodies to human programmed death receptor PD-1
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United States of America Patent
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Jan 15, 2013
Grant Date -
Oct 21, 2010
app pub date -
Jun 13, 2008
filing date -
Jun 18, 2007
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Abstract
Antibodies which block the binding of human Programmed Death Receptor 1 (hPD-1) to its ligands (hPD-L1 or hPD-L2) and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune response through the PD-I pathway is also disclosed.
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