4-arylazo-3,5-diamino-pyrazole compounds and use thereof
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United States of America Patent
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Jan 22, 2013
Grant Date -
Dec 18, 2008
app pub date -
Sep 1, 2005
filing date -
Sep 1, 2004
priority date (Note) -
Expired
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Abstract
A series of mono- and binuclear 4-arylazo-3,5-diamino-pyrazoles which are useful for inhibition of cyclin-dependent kinases (preferably CDK9). Hence they can be used as antimitotic-, pro-apoptotic and antiinflammatory drugs, in particular, in chemotherapy of cancer and asthma, therapy of psoriasis and parasitoses as those caused by fungi or protists, treatment of Alzheimer's disease or as antineurodegenerative drugs, or to suppress immunostimulation. These compounds are useful in a variety of utilities, including as intermediates in the preparation of flame-retardants, diagnostic reagents and therapeutics, including antivirals and immunosuppressors.
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