Expandable medical device with beneficial agent concentration gradient
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United States of America Patent
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Jan 29, 2013
Grant Date -
Apr 24, 2008
app pub date -
Oct 26, 2007
filing date -
Mar 30, 1998
priority date (Note) -
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Abstract
An expandable medical device has a plurality of elongated struts joined together to form a substantially cylindrical device, which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. At least one of the plurality of struts includes at least one opening extending at least partially through a thickness of the strut. A beneficial agent is loaded into the opening within the strut in layers to achieve desired temporal release kinetics of the agent. Alternatively, the beneficial agent is loaded in a shape which is configured to achieve the desired agent delivery profile. A wide variety of delivery profiles can be achieved including zero order, pulsatile, increasing, decrease, sinusoidal, and other delivery profiles.
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