Growth factor binding molecules
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United States of America Patent
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Jan 29, 2013
Grant Date -
Aug 19, 2010
app pub date -
Nov 19, 2009
filing date -
Mar 21, 2000
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Abstract
Growth factor binding molecules having a plurality of peptide loops attached to a non-peptide organic scaffold, preferably having pseudo-six amino acid peptide loops with four amino acid sidechains. The growth factor binding molecules specifically bind various growth factors and are suitable for treating a subject having tumors or restinosis. In one embodiment a platelet-derived growth factor binding molecule is disclosed that is used to inhibit tumor growth and angiogenesis in solid tumors.
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