Pharmaceutical compositions with improved dissolution
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United States of America Patent
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Jan 29, 2013
Grant Date -
Jun 22, 2006
app pub date -
Dec 24, 2003
filing date -
Feb 15, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to methods of screening mixtures containing a pharmaceutical compound and an excipient to identify properties of the pharmaceutical compound/excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a precipitation retardant and an optional enhancer.
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