Process for pure duloxetine hydrochloride
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United States of America Patent
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Jan 29, 2013
Grant Date -
Jan 8, 2009
app pub date -
Jan 4, 2007
filing date -
Jan 6, 2006
priority date (Note) -
Expired
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Abstract
A process for the preparation of pure Duloxetine hydrochloride comprises the steps of: a) reacting 1-(thiophen-2-yl)ethanone with dimethylamine hydrochloride, b) purifying the component in a solvent, c) reducing the component with an alkali metal borohydride, d) resolving the compound with a chiral acid, and treating the obtained compound with weak inorganic base, e) reacting the compound to give Duloxetine oxalate salt and f) converting the Duloxetine salt into its hydrochloride salt. Further the purifications of the obtained compound and of two intermediate products are described.
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