Cytotoxic T cell defined EGFR peptide and an optimized derivative peptide

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United States of America Patent

PATENT NO 8367069
APP PUB NO 20110171170A1
SERIAL NO

12959073

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention provides a polypeptide having a sequence of amino acids consisting of IXDFGLAKL (SEQ ID NO: 1), as well as a nucleic acid encoding the polypeptide, vector comprising the nucleic acid, cell comprising the vector, and compositions thereof. The invention also provides a method of inducing a T-cell response in a patient with epithelial cancer, and a method inhibiting epithelial cancer, wherein the methods comprise administering the composition of the invention. The invention further provides a method of stimulating a cell with the inventive polypeptide and a cell so stimulated.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION1ST FLOOR GARDNER STEEL CONFERENCE CENTER 130 THACKERAY AVENUE PITTSBURGH PA 15260

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Andrade, Pedro Pittsburgh, US 3 8
Ferris, Robert L Pittsburgh, US 1 0
Lopez-Albaitero, Andres Pittsburgh, US 8 50

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