Cells with altered fucosylation and producing antibodies therefrom
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United States of America Patent
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Feb 5, 2013
Grant Date -
Sep 10, 2009
app pub date -
Mar 24, 2009
filing date -
Oct 6, 2000
priority date (Note) -
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Abstract
The present invention relates to a cell and mammal in which GDP-mannose 4,6-dehydratase is knocked-out. The cell and mammal are useful for the production of an antibody molecule having high antibody-dependent cell-mediated cytotoxic activity, such as an antibody useful for treating various diseases. The cell and mammal are also useful for the production of a fragment of the antibody, and a fusion protein having the Fc region of the antibody.
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