Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4
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United States of America Patent
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Feb 5, 2013
Grant Date -
Oct 14, 2010
app pub date -
Apr 13, 2010
filing date -
Sep 29, 2005
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Expired
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Abstract
Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
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