Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto

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United States of America Patent

PATENT NO 8377666
APP PUB NO 20110129899A1
SERIAL NO

12904130

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Abstract

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The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.

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Patent Owner(s)

  • GENOMATICA, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Burgard, Anthony P Bellefonte, US 198 3036
Haselbeck, Robert San Diego, US 21 610
Niu, Wei Lincoln, US 41 512
Trawick, John D La Mesa, US 35 887

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