Devices and methods for inhibiting granulocyte activation by neural stimulation
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United States of America Patent
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Mar 5, 2013
Grant Date -
Mar 5, 2009
app pub date -
Aug 26, 2008
filing date -
Aug 27, 2007
priority date (Note) -
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Abstract
Described herein are methods, devices and systems for inhibition of granulocyte activation by appropriate stimulation of the vagus nerve. Methods of treating granulocyte-mediated disorders (including inflammatory disorders) by stimulating the vagus nerve to inhibit granulocyte activation (particularly neutrophil activation) are also described. Appropriate stimulation may be very low levels of stimulation, including stimulation that does not result in desensitization. The level of granulocyte activation may be detected and used to at least partially control stimulation.
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